ExoLiver®

BLB offers you the possibility to test your drug candidates in a human liver biological system: the unique and patent-protected ExoLiver platform. ExoLiver mimics the human liver microenvironment through the combination of co-culture of primary human liver cells, constant stimulation of the endothelial cell layer with microfluidic shear stress, and continuous paracrine interactions between all cell types. Due to its cutting-edge characteristics, ExoLiver has extremely high versatility allowing its use as experimental model to deeply characterize liver diseases pathophysiology, to understand the mechanisms of action of new chemical entities, or to investigate the possible hepatotoxicity of novel compounds.

ExoLiver, which allows co-culture of healthy or diseased hepatic cells, unravels key biological data obtained in a human-like system, therefore representing the ultimate pre-clinical step in your development pipeline.