BLB provides research services using top-quality pre-clinical models of liver disease, including liver cirrhosis, cholestatic liver disease & NASH. In addition, rodent models of liver transplantation and regeneration are also available.
BLB offers you the possibility to evaluate the efficacy and MOA of your compounds in standardized pre-clinical models of liver disease. Endpoint measurements include, among others, the clinical and physical examination of animals during treatment, characterization of the hepatic and systemic hemodynamics (including evaluation of portal pressure and intrahepatic microvascular function), biochemical analysis in plasma, tissue analysis (mRNA, protein, histology, fibrosis, etc), and analysis of the phenotype of the different hepatic cells sub-populations isolated from treated-animals.
BLB HAS THE FOLLOWING IN VIVO ANIMALS MODELS ALWAYS AVAILABLE.
BLB offers two reliable and reproducible models toxicant-induced chronic liver disease (CCl4 and TAA). May be evaluated at any time point during the progression of the disease, or once aCLD is present.
Bile duct ligation (BDL) model.
High fat diet-induced fatty liver, as pre-clinical model of NAFLD.
The unique BARNA MODEL model, which fulfils four key pathologic characteristics of human NASH liver: hepatocyte ballooning, inflammation, significant fibrosis and portal hypertension.
Let us perform your pre-clinical research on liver transplantation and/or regeneration, using both healthy and steatotic livers.