We are a contract research organization

Offers cutting-edge research services and consultancy in the field of liver diseases

We provide tailored reliable solutions to our partners for successful strategic decision making

At BLB we are fully committed to the sustainable development
of pre-clinical studies in hepatology

At BLB we are fully committed to the sustainable development of pre-clinical studies in hepatology. That's why we developed ExoLiver®, the first human liver-on-a-chip incorporating all major hepatic cell types where you can test the efficacy of new drug entities designed to beat liver diseases. However, we are aware that murine models are still essential to completely understand liver disease. Considering this, and with the aim of minimizing the use of animals, we carried out a series of internal investigations to properly understand the possible differences in the pathophysiology and molecular signature of chronic liver disease when comparing male and female rodents.

These studies, developed in collaboration with the Liver Vascular Biology Research Group of IDIBAPS, have now been finalized and the results published in the journal Biology of Sex Differences. Using two different models of chronic liver disease, we demonstrated that both sexes develop advanced disease in a similar manner. This was supported by comprehensive molecular and histological characterization. In addition, detailed transcriptomic analyses, comparison to human pathologies, and gene deconvolution provided further evidence and valuable insights for the design of future studies using both sexes.

With this contribution, we aim to reduce the number of experimental animals devoted to pre-clinical liver research, not only at a local level but globally.

Barcelona Liver Bioservices (BLB) is a CRO specialized in the field of Hepatology with an assorted portfolio of experimental models of liver disease. If after surfing our website you have questions or want to contact us, please do not hesitate. We will be happy to explain the models of chronic liver disease, MASH, transplant or regeneration that we always have available, and the way we envision liver research.

Hepatic steatosis can progress to a more severe form of fatty liver disease, called non-alcoholic steatohepatitis (NASH). In humans, livers with steatohepatitis exhibit steatosis, inflammation, hepatocyte injury and fibrosis. In a more advanced situation, it can progress to NASH-derived cirrhosis with significant fibrosis and portal hypertension. It is recognized that NASH-derived cirrhosis is a burden of disease in our Society, with no therapeutic option available.

In BLB we are truly conscious about the lack of a proper pre-clinical model to study the pathophysiology of NASH, and to test new biopharmaceutical compounds for this serious disease. For that, we invested significant part of our R&D; efforts to develop and validate a pre-clinical rat model for NASH: the BarNa model.

This model, based in a multi-hit strategy that combines diet-induced obesity and exposure to inflammatory injuries, shows reproducible results in terms of mimicking the key pathobiological features observed in human NASH: hepatocyte ballooning, inflammation, advanced fibrosis and significant portal hypertension. In addition, transcriptomic analysis of livers from BarNa animals using RNA seq evidenced high similarity with the human NASH transcriptomic profile.

The BarNa model was presented to the hepatology community in the annual meetings of the AASLD-2017 and EASL-2018, moreover its scientific quality and high applicability was recognized in the work entitled “New Rat Model of Advanced NASH Mimicking Pathophysiological Features and Transcriptomic Signature of The Human Disease” published in the peer-reviewed journal Cells.

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BLB works toward helping our partners to accelerate the development of new chemical entities to treat human liver disease. We value talent, experience and dedication of each of our employees.

The complete pre-clinical Solution

At BLB we are fully committed to the sustainable development
of pre-clinical studies in hepatology

With this contribution, we aim to reduce the number of experimental animals devoted to pre-clinical liver research, not only at a local level but globally.

BarNa Model®

See publication

BLB works toward helping our partners to accelerate the development of new chemical entities to treat human liver disease. We value talent, experience and dedication of each of our employees.

BLB seeks outstanding scientists, pharmacologists, biomedical engineers, computational biologists and business developers

If you are interested in joining the company that is changing the pre-clinical research in the fields of hepatology and toxicology, please contact us

The complete pre-clinical Solution

At BLB we are fully committed to the sustainable development of pre-clinical studies in hepatology​

With this contribution, we aim to reduce the number of experimental animals devoted to pre-clinical liver research, not only at a local level but globally.

BarNa Model®

See publication

BLB works toward helping our partners to accelerate the development of new chemical entities to treat human liver disease. We value talent, experience and dedication of each of our employees.

BLB seeks outstanding scientists, pharmacologists, biomedical engineers, computational biologists and business developers

If you are interested in joining the company that is changing the pre-clinical research in the fields of hepatology and toxicology, please contact us

At BLB we are fully committed to the sustainable development
of pre-clinical studies in hepatology