RODENT MODELS
BLB provides research services using top-quality pre-clinical models of liver disease, including liver cirrhosis, cholestatic liver disease & NASH. In addition, rodent models of liver transplantation and regeneration are also available

BLB offers you the possibility to evaluate the efficacy and MOA of your compounds in standardized pre-clinical models of liver disease. Endpoint measurements include, among others, the clinical and physical examination of animals during treatment, characterization of the hepatic and systemic hemodynamics (including evaluation of portal pressure and intrahepatic microvascular function), biochemical analysis in plasma, tissue analysis (mRNA, protein, histology, fibrosis, etc), and analysis of the phenotype of the different hepatic cells sub-populations isolated from treated-animals.

BLB HAS THE FOLLOWING IN VIVO ANIMALS MODEL
ALWAYS AVAILABLE

CHRONIC LIVER
DISEASE

LIVER CIRRHOSIS

BLB offers two reliable and reproducible models toxicant-induced chronic liver disease (CCl4 and TAA). May be evaluated at any time point during the progression of the disease, or once aCLD is present.

CHOLESTATIC LIVER DISEASE

Bile duct ligation (BDL) model.

FATTY LIVER
DISEASE

LIVER CIRRHOSIS

BLB offers two reliable and reproducible models toxicant-induced chronic liver disease (CCl4 and TAA). May be evaluated at any time point during the progression of the disease, or once aCLD is present.

CHOLESTATIC LIVER DISEASE

Bile duct ligation (BDL) model.

TRANSPLANTATION AND REGENERATION

Let us perform your pre-clinical research on liver transplantation and/or regeneration, using both healthy and steatotic livers.

The complete pre-clinical Solution

EXOLIVER®

BLB offers you the possibility to test your drug candidates in a human liver biological system: the unique and patent-protected ExoLiver platform
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TISSUES

BLB gives you the possibility to analyze your favourite gene or protein in liver tissue obtained from rodents and humans
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ORGAN
ON A CHIP

BLB offers high-quality services to create tailored organ on a chip platforms for preclinical human disease modelling
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RODENT
MODELS

BLB provides research services using topquality pre-clinical models of liver disease, including liver cirrhosis, cholestatic liver disease & NASH
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LIVER
CELLS

BLB provides research services using topquality pre-clinical models of liver disease, including liver cirrhosis, cholestatic liver disease & NASH
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STRATEGIC
CONSULTANCY

The virtuous combination of having deep experience in both pre-clinical and clinical phases of liver research
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BLB works toward helping our partners to accelerate the development of new chemical entities to treat human liver disease. We value talent, experience and dedication of each of our employees.

BLB seeks outstanding scientists, pharmacologists, biomedical engineers, computational biologists and business developers