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Scientific whitepapers
- Pathophysiology and therapeutic options for cirrhotic portal hypertension
The Lancet Gastroenterology and Hepatology
APRIL, 2024
This comprehensive review describes the pathophysiology of portal hypertension in cirrhosis, summarizes the current available therapeutic options and those under investigation, and proposes novel avenues of research.
- In Vitro Models for the Study of Liver Biology and Diseases: Advances and Limitations
cmghjournal
November, 2022
This review describes the currently available in vitro liver models and describe the advantages and disadvantages of each in the context of evaluating their use for the study of liver functionality, disease modeling, therapeutic discovery, and clinical applicability.
- Role of liver sinusoidal endothelial cells in liver diseases
Nature Reviews in Gastroenterology & Hepatology, 2021
This review describes the main functions and phenotypic dysregulations of LSECs in liver diseases and provides a comprehensive update of the role of LSECs as therapeutic targets for liver disease. We also discuss the open questions in the field of LSEC pathobiology and future avenues of research.
- Regression of portal hypertension: underlying mechanisms and therapeutic strategies
Hepatology International, 2021
This paper aims at providing an updated review of the currently available data regarding spontaneous and drug-promoted regression of portal hypertension, paying special attention to the clinical evidence. It also considers pathophysiological caveats that highlight the need for caution in establishing a new dogma that human chronic liver disease and portal hypertension is reversible.
- Novel therapeutics for portal hypertension and fibrosis in chronic liver disease
Pharmacology & Therapeutics, 2020
This review focuses on the pathophysiology of liver fibrosis and portal hypertension, in the context of liver cirrhosis, and provides a broad description of current treatments and potential therapeutic options
- Cirrhosis as new indication for statins
Gut, 2020
This article reviews the current knowledge on the potential applications of statins in chronic liver diseases, from its mechanistic background to objective evidence from clinical studies.
- Animal Models for Liver Disease - A Practical Approach for Translational Research
Journal of Hepatology, 2020
A comprehensive summary of mostly used experimental models of chronic liver disease, starting from early stages of fatty liver disease (non-alcoholic and alcoholic) to steatohepatitis and alcoholic liver disease, advanced cirrhosis and end-stage primary liver cancer
- Hepatic microcirculation and mechanisms of portal hypertension
Nature Reviews in Gastroenterology & Hepatology, 2019
This review describes the basis of liver microcirculatory dysfunction in cirrhotic portal hypertension and appraises the pre-clinical models used to study the liver circulation. It also provides a comprehensive summary of the promising therapeutic options to target the liver microvasculature in cirrhosis.
- Beta-blockers in cirrhosis: Evidence-based indications and limitations
JHEP Reports, 2019
This review summarises the evidence supporting current recommendations and restrictions of NSBB use in patients with cirrhosis
- Advances in therapeutic options for portal hypertension
Therapeutic Advances in Gastroenterology, 2018
The review critically summarizes the current knowledge in portal hypertension therapeutics, focusing on those strategies driven by the disease pathophysiology and underlying cellular mechanisms.